Effects of a SETD2 Mutation on DNA Damage Response in Renal Cell Carcinoma

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This project aimed to characterize the homologous repair (HR) defect in SETD2-mutated and wildtype RENCA cells and then evaluate potential therapeutic susceptibilities to PARP inhibition. The goal was to distinguish between two phenomena causing HR deficiency: lack of DNA double stranded break (DSB) detection or lack of repair after a DSB is detected.

Student Author: Jessica Peskin

Faculty Advisors: Thomas Mcguire and Dr. Phillip Abbosh

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Effects of a SETD2 Mutation on DNA Damage Response in Renal Cell Carcinoma

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