The aziridine ring is a versatile building block for organic synthesis.
Many biologically active compounds such as amino acids, beta-lactam
antibiotics, and alkaloids have been derived from aziridines.
Incorporating aziridine synthesis into an undergraduate organic
chemistry lab course would provide students valuable experience and
insight into a current synthesis methodology with many contemporary
applications. A survey of reported aziridine ring syntheses was
conducted to identify a procedure that accommodated instruction-related
limitations that include cost, safety, time, and sophistication. This
work focused on a methodology using pyridinium hydrobromide perbromide
as a catalyst for aziridination of alkenes using chloramineT.
Student Authors: Mahjabin Jaigirdar and Ayah Alkurdi
Faculty Advisors: Kevin Cannon and Ahmed Nuriye